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Breast Cancer – Causes, Symptoms and Treatment
Breast cancer is a malignant (cancerous) growth that begins in the tissues of the breast. During her lifetime, one in eight women will be diagnosed with breast cancer. Breast cancer is cancer of the breast tissue, which can occur in both women and men. Breast cancer may be one of the oldest known forms of cancerous tumors in humans. Worldwide, breast cancer is the fifth most common cause of cancer death (after lung cancer, stomach cancer, liver cancer and colon cancer). Breast cancer kills more women in the United States than any cancer except lung cancer. Today, breast cancer, like other forms of cancer, is believed to be the result of DNA damage. How this mechanism may occur stems from several known or hypothesized factors (such as exposure to ionizing radiation or viral mutagenesis). Some factors lead to increased mutation rate (estrogen exposure) and decreased gene repair (BRCA1, BRCA2 and p53). Alcohol generally seems to increase the risk of breast cancer.
Breast cancer can also occur in men, although rarely. Experts predict that 178,000 women and 2,000 men will develop breast cancer in the United States. There are several types of breast cancer. The first is that ductal carcinoma begins in the cells lining the ducts that bring milk to the nipple and accounts for over 75% of breast cancers. Second, lobular carcinoma begins in the milk-secreting glands of the breast, but its behavior is otherwise quite similar to ductal carcinoma. Other varieties of breast cancer can arise from the skin, fat, connective tissues, and other cells found in the breast. Some women have what is called HER2-positive breast cancer. HER2, short for human epidermal growth factor receptor-2, is a gene that helps control cell growth, division and repair. When cells have too many copies of this gene, cell growth accelerates.
Causes of breast cancer
The simple fact of being a woman is the main risk of breast cancer. Although men can also get the disease, it is about 100 times more common in women than in men. The risk of getting breast cancer increases as a woman ages. Nearly 8 out of 10 breast cancers occur in women aged 50 or over. About 5 to 10% of breast cancers are linked to changes (mutations) in certain genes. The most common genetic changes are those of the BRCA1 and BRCA2 genes. The risk of breast cancer is higher in women whose close relatives have this disease. Parents can be on the maternal or paternal side of the family. A woman with cancer in one breast is more likely to have new cancer in the other breast or in another part of the same breast. This is different from the first cancer that comes back Many experts now believe that the main reason for this is that they have faster growing tumours. Asian, Hispanic and Native American women have a lower risk of developing breast cancer. Certain types of abnormal biopsy results may be linked to a slightly higher risk of breast cancer.
Some pregnant women have been given the drug DES (diethylstilbestrol) because it was thought to reduce their risk of losing the baby. Recent studies have shown that these women (and their daughters who were exposed to DES while in the womb) have a slightly increased risk of developing breast cancer. Alcohol consumption is clearly linked to a slightly increased risk of breast cancer. Women who drink 1 glass a day have a very small increased risk. Those who drink 2 to 5 drinks a day are about 1½ times more likely than women who do not drink alcohol. The American Cancer Society suggests limiting how much you drink. Being overweight is linked to a higher risk of breast cancer, especially for women after a life change and if the weight gain occurred in adulthood. Also, the risk seems to be higher if the extra fat is around the waistline. Breastfeeding and pregnancy: Some studies have shown that breastfeeding slightly lowers the risk of breast cancer, especially if breastfeeding lasts 1 ½ to 2 years. This could be because breastfeeding decreases a woman’s total period count, just like pregnancy does. Women who started menstruating early (before age 12) or who changed their life (menopause) after age 55 have a slightly increased risk of breast cancer.
Breast Cancer Symptoms
3. Breast pain.
5. Nipple discharge.
6. Inverted nipple.
Breast cancer treatment
1. Hormone therapy (with tamoxifen).
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